Equine Getah Virus Infection : Pathological Study of Horses Experimentally Infected with the MI-110 Strain

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Abstract
A pathological study was performed on 5 horses experimentally exposed to the MI-110 strain of Getah virus. Main gross lesions with moderate enlargement of the lymph nodes of the whole body in all cases, and scattering maculae in the dermis and edema in the s.c. tissue in 2 cases, show rash. Histopathologically, the most outstanding lesion was lymphoid hyperplasia in all lymph nodes and in the spleen. Atrophy of the follicles of the spleen with degenerated lymphocytes was observed in 2 cases killed at the convalescent stage of disease. These histological findings in the lymphatic tissue appeared to be a reactive change attributable to immune responses. The cutaneous lesions were limited to the dermis with scattered maculae and characterized by perivascular and/or diffuse infiltration of lymphocytes, histiocytes and eosinophils, edematous alteration in the blood vessel walls and hemorrhagic foci. Mononuclear cell perivascular cuffing was observed in the cerebrum in 2 cases, and small hemorrhagic foci in the spinal cord in another case.

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