Radiation hybrid mapping.
- 1 September 1991
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (17) , 7477-7480
- https://doi.org/10.1073/pnas.88.17.7477
Abstract
A theory is developed to predict marker retention and conditional retention or loss in radiation hybrids. Applied to multiple pairwise analysis of a human chromosome 21 data set, this theory fits much better than proposed alternatives and gives a physical map consistent with other evidence and robust with respect to errors to typing. Radiation hybrids have great promise to provide order and physical location at two levels of resolution, spanning the techniques of linkage and restriction fragments and not limited to polymorphic loci.Keywords
This publication has 8 references indexed in Scilit:
- Parameters of the human genome.Proceedings of the National Academy of Sciences, 1991
- The CEPH consortium linkage map of human chromosome 1Genomics, 1991
- Guidelines for human linkage maps: An international system for human linkage maps (ISLM, 1990)Genomics, 1991
- Guidelines for human linkage maps An International System for Human Linkage Maps (ISLM, 1990)Annals of Human Genetics, 1991
- A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresisGenomics, 1991
- Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian ChromosomesScience, 1990
- Standard maps of chromosome 10Annals of Human Genetics, 1990
- MAP, an expert system for multiple pairwise linkage analysisAnnals of Human Genetics, 1989