Mononuclear phagocytes and eicosanoids: Aspects of their synthesis and biological activities
- 1 December 1989
- journal article
- review article
- Published by Springer Nature in Annals of Hematology
- Vol. 59 (6) , 475-485
- https://doi.org/10.1007/bf00329492
Abstract
Mononuclear phagocytes convert arachidonic acid and other unsaturated fatty acids from intracellular sources to a variety of oxygenated metabolites such as prostaglandins and leukotrienes which are secreted into the surrounding medium. Other oxidative products such as hydroxylinoleic acids are reacylated into cellular constituents. The underlying metabolic pathways are activated by numerous stimuli of exogenous or endogenous origin. Depending on the state of activation and cell differentiation, the organ of origin and the nature of the stimulus used, macrophages elaborate a distinct spectrum of oxidative arachidonic acid metabolites. The contribution of these metabolites to the proinflammatory properties of macrophages is twofold: As autocrine signals they modulate the synthesis of diverse macrophage products and they influence cellular functions of other cells such as T-lymphocytes.Keywords
This publication has 122 references indexed in Scilit:
- Lipoxygenase inhibitors suppress formation of tumor necrosis factor in, vitro and in, vivoBiochemical and Biophysical Research Communications, 1989
- Increased 13-hydroxyoctadecadienoic acid content in lipopolysaccharide stimulated macrophagesBiochemical and Biophysical Research Communications, 1987
- Involvement of lipoxygenases in the activation of mouse macrophages by endotoxinBiochemical and Biophysical Research Communications, 1986
- Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophagesBiochemical and Biophysical Research Communications, 1986
- Arachidonic acid metabolites regulate interleukin-1 productionBiochemical and Biophysical Research Communications, 1985
- Human peritoneal macrophages synthesize leukotrienes B4 and C4Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1983
- Leukotriene B4 induces human suppressor lymphocytesBiochemical and Biophysical Research Communications, 1982
- The role of prostaglandins in endotoxic activitiesJournal of Molecular Medicine, 1982
- Inhibition of leukotriene B4 synthesis in human polymorphonuclear leukocytes after exposure to meningococcal lipopolysaccharideBiochemical and Biophysical Research Communications, 1982
- Selective feed-back inhibition of the 5-lipoxygenation of arachidonic acid in human T-lymphocytesBiochemical and Biophysical Research Communications, 1981