Sequence‐specific DNA binding activity of rat cdc37‐related gene product
- 13 November 1995
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 375 (1-2) , 155-158
- https://doi.org/10.1016/0014-5793(95)01210-6
Abstract
The rat cdc37‐related gene product (RCdc37), which is possibly involved in the regulation of cell cycle progression, contains a putative basic/leucine zipper (bZIP) domain in its N‐terminal portion. In this study, we have identified a rat genomic sequence which can interact with RCdc37 using an in vitro binding assay. The specificity of this interaction was confirmed by gel retardation experiments. These results raise a possibility that RCdc37 might play an important role in the control of cell cycle progression via a sequence‐specific DNA binding mechanism.Keywords
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