A Phase I Open-Label, Dose-Escalation, Multi-Institutional Trial of Injection with an E1B-Attenuated Adenovirus, ONYX-015, into the Peritumoral Region of Recurrent Malignant Gliomas, in the Adjuvant Setting
Top Cited Papers
Open Access
- 1 November 2004
- journal article
- clinical trial
- Published by Elsevier in Molecular Therapy
- Vol. 10 (5) , 958-966
- https://doi.org/10.1016/j.ymthe.2004.07.021
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patientsCancer Gene Therapy, 2003
- Phase II Trial of Intravenous CI-1042 in Patients With Metastatic Colorectal CancerJournal of Clinical Oncology, 2003
- Regulatory Approvals of Pediatric Oncology Drugs: Previous Experience and New InitiativesJournal of Clinical Oncology, 2003
- Evidence that Replication of the Antitumor Adenovirus ONYX-015 Is Not Controlled by the p53 and p14 ARF Tumor Suppressor GenesJournal of Virology, 2002
- Phase I Trial of Intraperitoneal Injection of the E1B-55-kd-Gene-Deleted Adenovirus ONYX-015 (dl1520) Given on Days 1 Through 5 Every 3 Weeks in Patients With Recurrent/Refractory Epithelial Ovarian CancerJournal of Clinical Oncology, 2002
- The potential for efficacy of the modified (ICP 34.5−) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle studyGene Therapy, 2002
- Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activityGene Therapy, 2001
- Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trialGene Therapy, 2001
- An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor CellsScience, 1996
- Gene Transfer into Experimental Brain Tumors Mediated by Adenovirus, Herpes Simplex Virus, and Retrovirus VectorsHuman Gene Therapy, 1994