THE IMMEDIATE CARDIAC DEPRESSION BY ANAESTHETICS IN CONSCIOUS DOGS

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Abstract
The time course of circulatory changes during induction with halothane and/or nitrous oxide was studied in six healthy awake dogs. Beat-to-beat changes in cardiac performance were measured with chronically implanted aortic electromagnetic flowmeters, and pressures were recored from atria, pulmonary artery, and descending aorta. The dogs were trained to wear masks designed for delivering gases, and to acclimatize to the odour of halothane. Both 3 per cent halothane and 60 per cent nitrous oxide reduced peak aoritc flow and maximum acceleration within 4–8 seconds after the first breath. This depression was more pronounced with halothane than nitrous oxide, and was even more severe with the combinaton of halothane and nitrous oxide, and was even more severe with the combination of halothane and nitrous oxide. and was even more severe with the combination of halothane and nitrous oxide. Cardiac denervation when halothane and nitrous oxide olone and in combination produced the same immediate cardiac depression

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