Alterations of Mitochondrial Properties in Folate Nephropathy
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 24 (6) , 297-301
- https://doi.org/10.1159/000181740
Abstract
Folate nephropathy was selected as a model to study renal mitochondrial response after tubular injury. 20 h after injection, 14C-leucine incorporation was suppressed to 20–30% of control, 14C-mannose incorporation was 63–78% greater than control while the activities of succinic dehydrogenase and monoamine oxidase were unaltered. By 40 h, 14C-leucine incorporation had been restored to control values. Also, at 20 h, ATPase activity sensitive to oligomycin inhibition had increased by 45–73%, whereas K+-stimulated ATPase activity was reduced in the experimental mitochondrial fractions. The results are discussed along with other studies of mitochondria in experimental renal disease.Keywords
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