ENZYMES OF NUCLEIC ACID METABOLISM IN THE BRAINS OF YOUNG AND ADULT RATS

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Abstract
A number of precursors of RNA are incorporated several‐fold more readily into the RNA of brain slices from 10‐day‐old rats than into RNA of slices from adult animals. The brains of the young animals show moderately higher levels of some of the anabolic enzymes of RNA metabolism including RNA polymerase (nucleosidetriphosphate: RNA nucleotidyltransferase; EC 2.7.7.6) and substantially lower levels of the degradative enzymes, the nucleoside phosphorylases. The data suggest that all the enzymes work in a concerted fashion to produce an increased rate of synthesis in young animals rather than that any single controlling enzymic event is responsible.

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