Vaginal oxytetracycline concentrations.

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Abstract
Although tetracycline preparations are widely used in departments of genitourinary medicine or sexually transmitted diseases clinics, little is known of the concentrations of these preparations in genital secretions. For this reason a microbiological method was used for estimating oxytetracycline concentrations in vaginal secretions. These concentrations varied from 0.6-6.5 .mu.g/ml in 19 women who had had sexual contact with a man with non-specific urethritis and who were taking oxytetracycline dihydrate (250 mg) 4 times daily. They were well in excess of the minimum inhibitory concentration of oxytetracycline (0.2 .mu.g/ml) for strains of Chlamydia trachomatis isolated from the patients with positive culture results. Oxytetracycline (250 mg) 4 times daily may be a satisfactory regimen for treatment of chlamydial genital infection in women.