Hepatic Collagen Metabolism: Effect of Alcohol Consumption in Rats and Baboons
- 19 May 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 176 (4036) , 795
- https://doi.org/10.1126/science.176.4036.795
Abstract
Long-term ethanol feeding causes collagen accumulation in livers of rats and baboons. Activity of collagen proline hydroxylase in the liver is also stimulated, and incorporation of proline into collagen hydroxyproline in rat liver slices is significantly enhanced, a result indicating that increased synthesis is responsible, in part, for the collagen accumulation.Keywords
This publication has 11 references indexed in Scilit:
- Lactate, Lactate Dehydrogenase and Protocollagen Proline Hydroxylase in Rat Skin AutograftHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1971
- Collagen Biosynthesis in Normal and Cirrhotic Rat Liver SlicesExperimental Biology and Medicine, 1969
- Alcoholic fatty liver in man on a high protein and low fat dietThe American Journal of Medicine, 1968
- Increased protocollagen hydroxylase activity in the livers of rats with hepatic fibrosisBiochemical and Biophysical Research Communications, 1967
- Modifications of a specific assay for hydroxyproline in urineAnalytical Biochemistry, 1967
- A rapid assay for collagen proline hydroxylaseAnalytical Biochemistry, 1966
- Modified procedure for the assay of H3- or C14-labeled hydroxyprolineAnalytical Biochemistry, 1966
- Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets*Journal of Clinical Investigation, 1965
- Collagen and Cell Protein Synthesis by an Established Mammalian Fibroblast LineNature, 1964
- A specific method for the analysis of hydroxyproline in tissues and urineAnalytical Biochemistry, 1960