Amiodarone-induced neuropathy in a 71 yr old man is reported. First signs appeared 17 mo. after treatment (for coronary insufficiency) was started with 400 mg/day for 1 yr and continued with 200 mg/day. Examination in the 29th mo. disclosed a severe sensory and motor deficit of the limbs with distal predominancy. Motor nerve conuction velocity was strongly impaired without modification of distal latencies. Fundi were normal. The patient improved quickly after drug withdrawal. Rare similar cases reported in the literature and the clinical characteristics of amiodarone neuropathy are reviewed. Qualitative and quantitative light microscopic and EM studies of nerve, muscle and skin biopsies, including teased fibers preparations, disclosed a marked reduction of the number of myelinated fibers. Wallerian degeneration predominated (31%) over other segmental demyelination (25%). Numerous polymorphous lipid-laden lysosomes were present in Schwann cells, fibrocytes, pericytes, endothelial and muscle cells. These previously undescribed morphological findings are similar to those present in perhexiline maleate intoxications. Amiodarone neuropathy is a new neuropathy with drug-induced lipidosis.