Recent advances in molluscum contagiosum virus research
- 1 January 1997
- book chapter
- Published by Springer Nature
- Vol. 13, 35-47
- https://doi.org/10.1007/978-3-7091-6534-8_4
Abstract
Molluscum contagiosum virus (MCV) and variola virus (VAR) are the only two poxviruses that are specific for man. MCV causes skin tumors in humans and primarily in children and immunocompromised individuals. MCV is unable to replicate in tissue culture cells or animals. Recently, the DNA sequence of the 190 kbp MCV genome was reported by Senkevich et al. MCV was predicted to encode 163 proteins of which 103 were clearly related to those of smallpox virus. In contrast, it was found that MCV lacks 83 genes of VAR, including those involved in the suppression of the host response to infection, nucleotide biosynthesis, and cell proliferation. However, MCV possesses 59 genes predicted to code for novel proteins including MHC-class I, chemokine and glutathione peroxidase homologs not found in other poxviruses. The MCV genomic data allow the investigation of novel host defense mechanisms and provide new possibilities for the development of therapeutics for treatment and prevention of the MCV infection.Keywords
This publication has 63 references indexed in Scilit:
- Molluscum contagiosum in patients with human immunodeficiency virus infectionJournal of the American Academy of Dermatology, 1992
- Molecular epidemiological study of molluscum contagiosum virus in two urban areas of Western Japan by the in-gel endonuclease digestion methodArchiv für die gesamte Virusforschung, 1992
- Direct detection of Molluscum contagiosum virus in clinical specimens by in situ hybridization using biotinylated probeMolecular and Cellular Probes, 1992
- Giant molluscum contagiosum presenting as basal cell carcinoma in an acquired immunodeficiency syndrome patientJournal of the American Academy of Dermatology, 1988
- Dermatologic findings associated with human immunodeficiency virus infectionJournal of the American Academy of Dermatology, 1987
- Molluscum contagiosum occurring in an epidermoid cystJournal of Cutaneous Pathology, 1985
- Growth and regression of molluscum contagiosumJournal of the American Academy of Dermatology, 1983
- Lack of ?reactivating? activity in the molluscum contagiosum virusArchiv für die gesamte Virusforschung, 1967
- On the mechanism of the cytopathic changes produced in human amnion cell cultures by the molluscum contagiosum virusArchiv für die gesamte Virusforschung, 1966
- The micromanipulation and microdissection of the molluscum contagiosum inclusion bodyThe Journal of Pathology and Bacteriology, 1938