Protection against Anthrax Toxemia by Hexa- d -Arginine In Vitro and In Vivo
Open Access
- 1 January 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (1) , 602-605
- https://doi.org/10.1128/iai.72.1.602-605.2004
Abstract
The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-d-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.Keywords
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