EFFECT OF CYCLOLEUCINE ON DIBASIC AMINO-ACIDS IN CYSTINE RENAL CAPTATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (1) , 18-22
Abstract
Cycloleucine administration (synthetic amino acid) to rats produces a selective hyperaminoaciduria bearing on dibasic amino acids (lysine, arginine, ornithine) and cystine. Interference of cycloleucine with tubular reabsorption of these amino acids was studied in vitro using rat kidney cortex slices. When dibasic amino acids and cystine are at physiological concentrations, cycloleucine decreases their intracellular accumulation. However, effect of cycloleucine in vitro is not specific in its concentration; similar results are obtained with neutral amino acids such as .alpha.-alanine and valine. Inhibitory effects are not modified by the presence of several amino acids in the incubation medium. Apparently there is a dissociation between in vitro cellular accumulation and in vivo transepithelial transport.

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