MECHANISM OF EMERGENCE OF RESISTANCE TO STREPTOMYCIN IN FIVE SPECIES OF GRAM NEGATIVE BACILLI

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Abstract
Evidence is presented as proof of the mutational origin of streptomycin resistant variants of 5 different spp.[long dash]E. coli, Salmonella sp., Shigella sp., S. typhosa and Pseudomonas aeruginosa. This evidence is three-fold: demonstration of their independence of the action of streptomycin by their continuous irregular occurrence with different prevalence in independent cultures of same population size and strain; transmission of resistance unchanged through many subcultures in the absence of streptomycin; a low rate of occurrence of resistant variants. Therapeutic implications suggest the possibility that continuation of streptomycin after emergence of resistance may make the infection worse. Organisms resistant to streptomycin may be sensitive to other agents like the sulfa drugs.