ACTION OF CORTISONE ON CARDIOVASCULAR-RENAL EFFECTS OF DESOXYCORTICOSTERONE ACETATE

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Abstract
Cortisone, alone and in combination with desoxycorticosterone acetate (DCA), was studied with regard to its cardiovascular-renal action and its effects on plasma electrolytes. In addition, routine histologic sections of kidney, heart, adrenal, spleen, pancreas, intestine, testis and pituitary were examined. The blood pressure rise which ordinarily follows the admn. of DCA did not occur in the presence of cortisone. The heart and kidney wt. increases caused by DCA were, however, not inhibited by cortisone. Thus, cortisone cannot be considered antagonistic to the cardiovascular-renal effects of DCA. Cortisone caused an elevation of plasma K and chloride, effects opposite to those of DCA, but overshadowed by the latter when both steroids were given together. Cortisone caused renal glomerular lesions which were additive to those of DCA when both steroids were given together. The histological findings suggest that cortisone, among its other effects, tends to decrease the number of eosinophils in the anterior pituitary. DCA was admd. in pellets, while the cortisone acetate was injd. as 1 mg. twice daily of a saline suspension of micro-crystals.