Effect of Topical Application of Copper in Combination with Fluoride in Drinking Water on Experimental Caries in Rats

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Abstract
A cariostatic effect of copper sulfate was observed in rats in a recent study by Afseth et al. In the present study, effects of the combination of topically applied copper with fluoride in the drinking water were determined. Groups of animals receiving a combination of copper and fluoride developed significantly less caries than the groups given either substance alone at the corresponding concentrations. Reduced numbers of Streptococcus mutans were isolated from animals receiving Cu treatment. This reduction was most pronounced in rats treated with elevated Cu concentrations alone and in combination with F.