Studies on the application of the relative-dose-response test for assessing vitamin A status in older adults
Open Access
- 1 September 1992
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 56 (3) , 543-547
- https://doi.org/10.1093/ajcn/56.3.543
Abstract
We investigated the time course and the reproducibility of the relative-dose-response (RDR) test for assessing vitamin A status in older adults. The maximum plasma retinol response to 480 retinol equivalents (RE) of retinyl palmitate in abnormal responses was at 6 or 7 h after dosing compared with the 5-h sampling interval recommended by others for younger adults and children. With respect to reproducibility, the diagnostic concordance of two RDR tests at 7-d intervals in 14 elders was 71%. In 29% of tests, one test was abnormal and the other normal. Linear regression of the two RDR values in these 14 subjects gave a correlation coefficient of −0.08. We conclude that the procedure for the RDR should be modified when applied to persons > 60 y of age, and that multiple repetitions of the test are needed to provide a stable indication of vitamin A stores in an elderly individual.Keywords
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