CONTROL OF INTERMITTENT POSITIVE PRESSURE BREATHING (IPPB) BY EXTRACORPOREAL REMOVAL OF CARBON DIOXIDE

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Abstract
Lambs (5) were anesthetized with pentobarbitone, paralyzed with tubocurarine, mechanically ventilated and connected to a membrane lung to permit removal of CO2. When part of the CO2 was removed in this manner, the tidal volume was decreased to keep PaCO2 [arterial pressure of CO2] constant. When 70% of CO2 was removed by the membrane lung, total ventilation was reduced by 50%, peak inspiratory pressure was decreased by 45% and PaO2 [arterial pressure of O2] was kept constant by increasing the inspired O2 fraction from 0.21 to 0.27%. The removal of CO2 by a membrane during positive pressure breathing could decrease barotrauma, particularly in poorly compliant lungs. Technically, the extracorporeal removal of CO2 was a relatively simple procedure.

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