Electrostatic Zipper Motif for DNA Aggregation

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Abstract
Counterion specificity of DNA condensation is rationalized from a theory of electrostatic interaction between helical molecules that accounts for different charge distribution patterns. An axial charge separation due to ion binding in helical grooves allows close approach of opposite charges along the DNA-DNA contact and forms an electrostatic “zipper” that “fastens” the molecules together. Predictions of the theory are in agreement with experimental data.