Cytomegalovirus Complement-Fixing Antibody in Microcephaly
- 1 September 1966
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 275 (9) , 476-479
- https://doi.org/10.1056/nejm196609012750905
Abstract
THE report with Weller, in 1962, of microcephaly in 14 of 17 infants with generalized cytomegalic inclusion disease established the association of this Central-nervous-system defect with intrauterine cytomegalovirus infection.1 In 1964 Medearis2 demonstrated complement-fixing antibody in 6 of 7 congenitally infected infants with cytomegalic inclusion disease. The present study employs the complement-fixation test to detect cytomegalovirus antibody in 17 infants with typical cytomegalic inclusion disease and 41 microcephalic infants and children without typical symptoms of extraneural disease.Materials and MethodsThe micro complement-fixation test originally introduces by Takátsy3 and modified by Sever and his associates4 was employed. Cytomegalovirus antigen was . . .Keywords
This publication has 3 references indexed in Scilit:
- Acquired Cytomegalovirus InfectionNew England Journal of Medicine, 1965
- The incidence of infection with cytomegalovirus in a normal population: A serological study in Greater LondonEpidemiology and Infection, 1965
- Virologic and Clinical Observations on Cytomegalic Inclusion DiseaseNew England Journal of Medicine, 1962