PANTETHINE AND PANTOTHENATE EFFECT ON THE COA CONTENT OF RAT-LIVER
- 1 January 1984
- journal article
- research article
- Vol. 54 (2-3) , 211-216
Abstract
The role of pantethine as a precursor of CoA in rat liver was examined. Pantethine induces a significant increase in the total CoA content both in perfused liver and in liver homogenate, while it fails to affect the mitochondrial CoA content when added to isolated mitochondria. Pantethine is more efficient than pantothenate in inducing the synthesis of CoA in rat liver, even in the presence of added cysteine. The possible metabolic implications are discussed.This publication has 12 references indexed in Scilit:
- Rate-limiting step and control of coenzyme A synthesis in cardiac muscle.Journal of Biological Chemistry, 1982
- The effect of ethanol and acetaldehyde on [14C]pantothenate incorporation into CoA in cultured rat liver parenchymal cellsArchives of Biochemistry and Biophysics, 1982
- Effects of pantethine on different models of experimental hyperlipidemia in rodents: A comparison with clofibratePharmacological Research Communications, 1982
- Regulation of the Biosynthesis of CoA at the Level of Pantothenate KinaseEuropean Journal of Biochemistry, 1982
- Effect of pantethine on lipoprotein profiles and HDL subfractions in experimentally hypercholesterolemic rabbitsAtherosclerosis, 1982
- THE EFFECT OF PANTETHINE, A PRECURSOR OF COENZYME-A, ON BILE-ACIDS AND LIPIDS IN RATS FED WITH A CHOLESTEROL DIET1981
- Effect of pantethine on cholesterol ester metabolism in rat arterial wallAtherosclerosis, 1980
- Mitochondrial biosynthesis of coenzyme ABiochemical and Biophysical Research Communications, 1979
- Variations in tissue contents of coenzyme A thio esters and possible metabolic implicationsBiochemical Journal, 1964
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951