Toll-like receptors and cancer

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Abstract
The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. This Perspective discusses how the function of the Toll-like receptors may relate to these processes in the context of carcinogenesis. Toll-like receptors (TLRs) are a family of pattern recognition receptors that are best-known for their role in host defence from infection. Emerging evidence also suggests that TLRs have an important role in maintaining tissue homeostasis by regulating the inflammatory and tissue repair responses to injury. The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis.