Multiple Sclerosis: Correlation between Immunoglobulin-G in Cerebrospinal Fluid and Brain
- 25 November 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3752) , 1044-1046
- https://doi.org/10.1126/science.154.3752.1044
Abstract
There is a positive correlation between the concentration of immunoglobulin-G in plaques of demyelination due to multiple sclerosis (as well as in white matter of normal appearance) and the concentration of this globulin in the cerebrospinal fluid. The tentative conclusion drawn from these results was that, in patients with multiple sclerosis, the increase in immuno-globulin-G in the cerebrospinal fluid is a reflection of an excess of this globulin in the brain.This publication has 4 references indexed in Scilit:
- Multiple Sclerosis: Brain Immunoglobulin-G and AlbuminNature, 1967
- Gangliosides and Glycerophospholipids in Multiple Sclerosis White MatterArchives of Neurology, 1967
- Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methodsThe American Journal of Medicine, 1948
- AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS 1Journal of Clinical Investigation, 1942