Inositol phosphate production following α1‐adrenergic, muscarinic or electrical stimulation in isolated rat heart
- 6 October 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 206 (2) , 292-298
- https://doi.org/10.1016/0014-5793(86)80999-1
Abstract
A possible participation of polyphosphoinositide metabolism in the excitation-contraction coupling in heart was investigated. Isolated rat ventricles prelabelled with myo-[2-3H]inositol were stimulated by conditions that increase mechanical activity. Both noradrenaline and carbachol increased the basal level of IP3 IP2 and IP by the activation of α1-adrenergic and muscarinic receptors, respectively. Electrical stimulation accelerated inositol lipid degradation by phospholipase C thus enhancing the IP3 level as compared to quiescent ventricles. It is proposed that IP3 may be involved in excitation-contraction coupling in cardiac tissue.Keywords
This publication has 25 references indexed in Scilit:
- Evidence that phosphoinositide response is mediated by α1-adrenoceptor stimulation, but not linked with excitation-contraction coupling in cardiac muscleBiochemical and Biophysical Research Communications, 1986
- Inositol 1,4,5-trisphosphate enhances Ca2+-sensitivity of the contractile mechanism of chemically skinned rabbit skeletal muscle fibresBiochemical and Biophysical Research Communications, 1986
- A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophilsNature, 1986
- Binding sites for inositol trisphosphate in the bovine adrenal cortexBiochemical and Biophysical Research Communications, 1985
- Alpha 1-adrenergic and muscarinic cholinergic stimulation of phosphoinositide hydrolysis in adult rat cardiomyocytes.Circulation Research, 1985
- The Molecular Basis of Communication within the CellScientific American, 1985
- Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscleNature, 1985
- Inositol trisphosphate does not release Ca2+ from permeabilized cardiac myocytes and sarcoplasmic reticulumFEBS Letters, 1985
- Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 1984
- Inositol phospholipids and cell surface receptor functionBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975