Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease
- 10 January 1981
- Vol. 282 (6258) , 93-94
- https://doi.org/10.1136/bmj.282.6258.93
Abstract
The activity of the noradrenergic marker enzyme dopamine-beta-hydroxylase was measured in brains removed postmortem from control patients and patients with Alzheimer's disease. Enzyme activity was decreased in the frontal and temporal cortices and hippocampus in patients with Alzheimer's disease, but was within the normal range in patients with depression, multiinfarct dementia, and terminal coma. The decrease in enzyme activity in Alzheimer's disease may reflect an abnormality of cortical noradrenergic fibres in some patients with the disease.This publication has 15 references indexed in Scilit:
- ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?The Lancet, 1979
- Memory Impairment in Korsakoff's Psychosis: A Correlation with Brain Noradrenergic ActivityScience, 1978
- REGIONAL DISTRIBUTION OF ENZYMES ASSOCIATED WITH NEUROTRANSMISSION BY MONOAMINES, ACETYLCHOLINE AND GABA IN THE HUMAN BRAINJournal of Neurochemistry, 1978
- ALUMINUM LEVELS IN BRAIN IN ALZHEIMERS-DISEASE1978
- The activities of brain dopamine-?-hydroxylase and catechol-O-methyl transferase in schizophrenics and controlsPsychopharmacology, 1978
- Neurotransmitter enzyme abnormalities in senile dementiaJournal of the Neurological Sciences, 1977
- Selective vulnerability of neurones in organic dementiaNature, 1977
- SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASEPublished by Elsevier ,1976
- Some observations on the interaction of dopamine-β-hydroxylase and its natural inhibitors in the rat brainCanadian Journal of Biochemistry, 1976
- [Catecholaminergic axons in the human cerebral cortex. Observation by histofluorescence of cerebral biopsies in 2 cases of Alzheimer's disease].1976