Variable Sequences in the Long Terminal Repeat and Its Downstream Region of Some of HIV Type 1 CRF01_AE Recently Distributing among Thai Carriers

Publisher Website
Google Scholar
Abstract
Human immunodeficiency virus type 1 (HIV-1) proviral DNA sequences in and downstream of the 5′ long terminal repeat (LTR) were compared among samples obtained from 13 HIV-1 CRF01_AE-infected individuals in Thailand from 1998 to 1999. Eleven individuals had highly conserved sequences compared with previously reported CRF01_AE viruses. However, T cell-specific factor (TCF)-1α motif, which is located just beside the 3′ terminus of the nef sequence, was duplicated in 2 out of the 13 subjects, one of whom had also lost the 24 nucleotides next to the 3′ of the primer-binding site. Thus, several characteristics of CRF01_AE LTR and gag-leader sequence were identified in some samples recently obtained in Thailand.