This report deals with the comparative merits of iron, whole liver, liver extract and various combinations of these substances in the treatment of patients with anemia due to chronic hemorrhage or chronic chlorosis. These two interesting types of secondary anemia frequently escape both recognition and treatment. The former is the result of the persistent loss of small amounts of blood over a long period of time. Such patients usually seek surgical advice because of menorrhagia or bleeding from the intestinal tract. The second type is not associated with any recognizable hemorrhage but occurs in young or middle-aged women and is characterized by a relatively low level of hemoglobin with an essentially normal red blood cell count. Since the publication of a previous paper,1a new and more accurate method of studying anemia, recently utilized by Murphy, Lynch and Howard,2has been employed in this investigation. These authors used