HORMONAL REQUIREMENTS FOR THE UTERINE ATTACHMENT REACTION AND BLASTOCYST IMPLANTATION IN THE MOUSE, HAMSTER AND GUINEA-PIG

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Abstract
Before implantation occurs, a lumen containing secretion can be demonstrated in the uterus of the rat, mouse, hamster and guinea-pig. This luminal space disappears when implantation occurs, the apposing luminal surfaces of the mucosa coming into close contact. This phenomenon has been named the `attachment reaction' of the uterine epithelium (Nilsson, 1970). In the rat, the preimplantation appearance of the uterine mucosa can be maintained, by giving progesterone during experimentally delayed implantation (Nilsson, 1966) or by giving progesterone to spayed rats (Ljungkvist, unpublished). Implantation and the attachment reaction do not take place until oestrogen is given (Mayer & Nilsson, 1966). In the hamster, implantation occurs without the addition of oestrogen when progesterone is given to animals ovariectomized early in pregnancy (Prasad, Orsini & Meyer, 1960; Harper, Dowd & Elliott, 1969) and in the guinea-pig, even

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