Fish Oils and Low-Molecular-Weight Heparin for the Reduction of Restenosis After Percutaneous Transluminal Coronary Angioplasty
- 1 October 1996
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 94 (7) , 1553-1560
- https://doi.org/10.1161/01.cir.94.7.1553
Abstract
Background Percutaneous transluminal coronary angioplasty (PTCA) is complicated by restenosis within 6 months in >40% of patients. Theoretical, animal experimental, and human epidemiological and clinical trial findings have suggested that fish oils (n-3) might reduce restenosis. Low-molecular-weight heparin (LMWH) has reduced cellular proliferation and restenosis in several experimental systems. Methods and Results We randomized 814 patients to fish oils (5.4 g n-3 fatty acids) or placebo a median of 6 days before PTCA and continued for 18 weeks. At the time of sheath removal, 653 patients with at least one successfully dilated lesion were randomized to LMWH (30 mg SC BID) or control for 6 weeks in a 2×2 factorial design. Follow-up with quantitative coronary angiography (QCA; target, 18 weeks) was interpretable on 96% of these patients. Restenosis rates per patient were for n-3, 46.5%; placebo, 44.7%; LMWH, 45.8%; and control, 45.4%. Restenosis rates per lesion were for n-3, 39.7%; placebo, 38.7%; LMWH, 3...Keywords
This publication has 28 references indexed in Scilit:
- A meta-analysis of randomized trials of calcium antagonists to reduce restenosis after coronary angioplastyThe American Journal of Cardiology, 1994
- Guidelines for percutaneous transluminal coronary angioplastyJournal of the American College of Cardiology, 1993
- Effect of eicosapentaenoic acid on restenosis rate, clinical course and blood lipids in patients after percutaneous transluminal coronary angioplastyAustralian and New Zealand Journal of Medicine, 1990
- Usefulness of fish oil supplements in preventing clinical evidence of restenosis after percutaneous transluminal coronary angioplastyThe American Journal of Cardiology, 1989
- Effect of 18- to 24-hour heparin administration for prevention of restenosis after uncomplicated coronary angioplastyAmerican Heart Journal, 1989
- Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty AcidsNew England Journal of Medicine, 1988
- Cardiovascular Effects of n-3 Fatty AcidsNew England Journal of Medicine, 1988
- Inhibition of Atherosclerosis by Cod-Liver Oil in a Hyperlipidemic Swine ModelNew England Journal of Medicine, 1986
- In Vivo Indexes of Platelet and Vascular Function during Fish-Oil Administration in Patients with AtherosclerosisNew England Journal of Medicine, 1986
- Effect of heparin on vascular smooth muscle cells. I. Cell metabolismJournal of Cellular Physiology, 1985