Ureas as Backbone Replacements for the Phosphodiester Linkage in Oligonucleotides
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (01) , 57-61
- https://doi.org/10.1055/s-1994-22737
Abstract
The synthesis of thymidine dimers containing an urea moiety in place of the natural phosphodiester backbone is described. These new dimers were incorporated in oligodeoxyribonucleotides and melting temperatures (Tm) of the DNA/RNA and DNA/DNA duplexes as well as the nuclease resistance of these single strands were determined. In addition, molecular modeling studies are reported.Keywords
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