Transposition of 9q34 and 22 (q11?qter) regions has a specific role in chronic myelocytic leukemia

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Abstract
Six cases are reported of variant Ph′ translocations found among 240 patients with Ph′-positive CML. Five cases had a three-chromosome rearrangement involving, in addition to chromosomes 9 and 22, chromosomes 7, 4, 2(two), and 3 respectively, and one case had a two-chromosome rearrangement 22/5. A review of the literature revealed that three- and two-chromosome variant Ph′ translocations are observed with equal frequency. It is postulated that all variant translocations are indeed three-chromosome rearrangements, that the specific event for the formation of the Ph′ chromosome is the reciprocal translocation 9/22, and that the transposition of regions 9q34 and 22 (q11→qter), plays a major role in the development of CML.