Transplantation of Monodispersed Rat Thyroid Cells: Hormonal Effects on Follicular Unit Development and Morphology

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Abstract
An in vivo model system for the study of the growth and development of organized thyroid epithelial structures is described. These epithelial structures respond to various hormonal manipulations in a manner identical to that described for the thyroid gland in situ. The light and ultrastructural morphology of the follicular epithelial cells correlate well with that described for thyroid cells in intact glands exposed to similar hormonal manipulations. Follicular units which develop after transplantation of monodispersed thyroid cells serve as excellent models for the study of thyroid development and response in vivo. This model provides the further advantage of a quantitative approach for the investigation of epithelial cell growth and differentiation, of responses to environmental fluctuations, aspects of cell structure and function, and carcinogenesis.

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