RELATIONSHIP OF BIOCHEMICAL AND HISTOMETRIC DETERMINANTS OF UREMIC BONE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 103  (5) , 228-230
Abstract
Simultaneous histometric and biochemical analyses were performed on 16 bone biopsy specimens taken from 8 patients with chronic renal failure. The bone C and P contents are inversely related to the relative volume of microscopically measured, nonmineralized bone matrix (osteoid) and to the percentage of trabecular surface covered by this tissue. The Mg content of uremic bone is positively correlated with the quantity of osteoid. Skeletal C and P contents correlate inversely with the osteoblast population, and P relates directly to the volume of trabecular bone. Bone hydroxyproline content does not correlate significantly with any histometric variable. Since biochemical conclusions can be drawn about the uremic skeleton from morphological observations, these data may facilitate interpretation of nondecalcified histological secretions of bone.

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