Synthesis of Nucleotide Lipophilic Prodrugs Containing Two Inhibitors Targeted Against Different Phases of the HIV Replication Cycle

1 May 1995

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 14 (3) , 783-787
https://doi.org/10.1080/15257779508012471

Abstract

We describe the preparation of nucleoside acyl 5′-di or 5′-triphosphates, containing a nucleoside analog moiety and 13-oxa-myristic acid as lipophilic chain. At physiological pH these products liberated exclusively the corresponding nucleotides.

Keywords

DIFFERENT PHASES
NUCLEOTIDE LIPOPHILIC
PRODRUGS CONTAINING
LIPOPHILIC PRODRUGS
TWO INHIBITORS
HIV REPLICATION
INHIBITORS TARGETED
REPLICATION CYCLE

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