Serum uric acid as an index of impaired oxidative metabolism in chronic heart failure

Open Access
Publisher Website
Google Scholar
Abstract
Elevated serum uric acid concentrations have been observed in clinical conditions associated with hypoxia. Since chronic heart failure is a state of impaired oxidative metabolism, we sought to determine whether serum uric acid concentrations correlate with measures of functional capacity and disease severity. Fifty nine patients with a diagnosis of chronic heart failure due to coronary heart disease (n=34) or idiopathic dilated cardiomyopathy (n=25) and 20 healthy controls underwent assessment of functional capacity. Maximal oxygen uptake (MVO2) and regression slope relating to minute ventilation to carbon dioxide output (VE-VCO2) were measured during a maximal treadmill exercise test. Metabolic assessment consisted of measuring serum uric acid and fasting lipids, and insulin sensitivity, obtained by minimal modelling analysis of glucose and insulin responses during an intravenous glucose tolerance test. Clustering of indices of functional disease capacity and metabolic factors was explored using factor analysis and multivariate regression analysis. Compared to 20 healthy controls, patients with chronic heart failure had a 52% lower MVO2 (PPP2 (r= − 0·50) (both P2 slope (r=0·45), and NYHA functional class (r=0·36) (both P2 and VE-VCO2, slope. In multivariate regression analysis, serum uric acid concentrations emerged as a significant predictor of MVO2, exercise time (both P2 slope and NYHA functional class (both P2 suggests that in chronic heart failure, serum uric acid concentrations reflect an impairment of oxidative metabolism.

This publication has 0 references indexed in Scilit: