A Convenient Synthesis of the Potent Mutagen 3,4,8-Trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.
- 1 January 1985
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 39b (3) , 213-217
- https://doi.org/10.3891/acta.chem.scand.39b-0213
Abstract
The highly mutagenic 4,8-DiMeIQx [3,4,8-trimethyl-3H-imidazo[4,5-f] quinoxalin-2-amine] was synthesized in 13% overall yield from 2-fluoro-5-nitrotoluene in 8 operations. The average operation yield was 83%. The reaction sequence used gave, in addition to [4,8-DiMeIOx] the isomer 3,4,7-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine (4,7-DiMeIQx).This publication has 4 references indexed in Scilit:
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