RENAL ONCOCYTOMA - A PHENOTYPIC AND GENOTYPIC ENTITY OF RENAL PARENCHYMAL TUMORS

  • 1 May 1989
    • journal article
    • research article
    • Vol. 134  (5) , 967-971
Abstract
The light and electron microscopic morphology of two renal parenchymal tumors was consistent with the diagnosis of renal oncocytoma. Both tumors had a mosaic chromosome pattern of cells with normal and abnormal karyotypes. No recurrent chromosome aberration and also no rearrangement of chromosome 3p was found. Restriction analysis of the mitochondrial DNA revealed a new autoradiographic band at about 50 basepairs in size occurring exclusively in oncocytomas. The possible use of these findings in the diagnosis of renal oncocytomas is discussed.