CHANGES IN BLOOD VOLUME IN PATIENTS WITH EDEMA OF RENAL ORIGIN

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Abstract
A study has been made of the blood volume in 5 cases of renal edema by means of the CO method. The results obtained indicate that: (1) The blood volume is abnormally low when edema is at its height, that it increases as the edema disappears and may fall again if the edema subsequently reappears. (2) In a case uncomplicated by anemia the cell volume is normal and the changes are confined to the plasma volume. (3) When anemia is present there is a diminution in cell volume which is more marked the higher the degree of anemia. In anemic cases the plasma volume is less definitely reduced; and when diuresis sets in the plasma volume may rise above the normal as though to compensate for the diminished cell volume and to bring the total blood volume up to normal.

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