Lithium and Brain Choline Levels

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Abstract
To the Editor: We read with interest a recent letter to the Journal from Jope et al.1 reporting that choline accumulates in erythrocytes of patients treated with lithium. Earlier studies had demonstrated a reduced influx of choline into red blood cells of patients taking lithium,2 leading Jope et al. to conclude that lithium preferentially inhibits choline efflux. Recent experiments in our laboratory on the transport of serum choline into rat brains parallel their work on human erythrocytes and confirm the importance of considering both influx and efflux during study of transport phenomena. Our work suggests that chronic lithium treatment predominantly . . .

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