NATRIFERIC AND HYDRO-OSMOTIC EFFECTS ON THE TOAD BLADDER OF VASOPRESSIN ANALOGUES WITH SELECTIVE ANTIDIURETIC ACTIVITY

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Abstract
SUMMARY: The effects of vasopressin analogues with selective antidiuretic activity have been tested on the isolated toad bladder. Analogues of oxytocin and 8-Arg vasopressin lacking the terminal amino group had reduced effects on water (hydro-osmotic effect) and sodium (natriferic effect) transfer across the bladder. The natriferic effect of deamino-8-Arg vasopressin was reduced 3·5 times more than its hydro-osmotic effect. Deamino-2-Phe, 8-Arg vasopressin had a reduced hydro-osmotic action compared with deamino-8-Arg vasopressin (6 times less) while the reduction of the natriferic effect was far more pronounced (68 times). The selective antidiuretic, compared to pressor, potency of these analogues is discussed in relation to their selective hydro-osmotic compared to natriferic potency.