RECOVERY OF INJECTED OESTROGENIC SUBSTANCES FROM RABBIT URINE

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Abstract
Experiments have shown that the amount of administered oestrogen that can be recovered from the urine of both human subjects and animals is generally very small. Luchsinger and Voss [1929], Kemp and Pedersen-Bjergaard [1933], Zondek [1934], Robson, MacGregor, Illingworth, and Steere [1934], and Mazer and Israel [1936], have performed experiments of this kind on human patients and have recovered only 3–12% of administered oestrone from the urine. Smith and Smith [1931] working with rabbits have shown that after the injection of 600–700 rat units of oestrone, 30 rat units or approximately 5% could be recovered from the urine, whilst Westerfield and Doisy [1937] have performed similar experiments with monkeys and have found that only 1·5–5·3% of injected oestrone could be recovered even from an ovariectomized-hysterectomized animal. Pincus and Zahl [1937], however, have studied the oestrogen metabolism in rabbits under varying conditions and in some cases claim recoveries up to 98%

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