Renal Clearance of Polythiazide

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Abstract
The renal clearance of a new diuretic, C14 labeled polythiazide, 2-methyl-3-(0,M-trffluoroethyl-thiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-l,2,4-benzothiadiazine, 1,1-dioxide was studied in dogs under Na pentobarbital anesthesia. The drug clearance creatinine clearance ratio for polythiazide was lower than that for other benzothiadiazines. Experimental data indicate that the low clearance of polythiazide is due to drug binding by plasma proteins, and to reabsorption in the distal renal tubule. There is evidence to indicate that polythiazide is also secreted by the renal tubule.