A Randomized Trial of the Angiotensin-Receptor Blocker Valsartan in Chronic Heart Failure
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- 6 December 2001
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (23) , 1667-1675
- https://doi.org/10.1056/nejmoa010713
Abstract
Actions of angiotensin II may contribute to the progression of heart failure despite treatment with currently recommended drugs. We therefore evaluated the long-term effects of the addition of the angiotensin-receptor blocker valsartan to standard therapy for heart failure.Keywords
This publication has 26 references indexed in Scilit:
- Up-Regulation of AT1 and AT2 Receptors in Postinfarcted Hypertrophied Myocytes and Stretch-Mediated Apoptotic Cell DeathThe American Journal of Pathology, 2000
- The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart FailureNew England Journal of Medicine, 1999
- The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trialThe Lancet, 1999
- Effects of angiotensin-II infusion at pressor and subpressor doses on endothelbv-1 plasma levels in healthy menLife Sciences, 1997
- The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart FailureNew England Journal of Medicine, 1996
- Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression.Journal of Clinical Investigation, 1994
- Tissue renin-angiotensin system in myocardial hypertrophy and failureArchives of internal medicine (1960), 1993
- CIRCULATING ANGIOTENSIN II LEVELS UNDER REPEATED ADMINISTRATION OF LISINOPRIL IN NORMAL SUBJECTSClinical and Experimental Pharmacology and Physiology, 1992
- Effects of Enalapril on Mortality in Severe Congestive Heart FailureNew England Journal of Medicine, 1987
- Vasodilator Therapy for Heart FailureCirculation, 1973