INTERMITTENT ISONIAZID THERAPY FOR MICE

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Abstract
The therapeutic effects of isoniazid given continuously and intermittently were compared in tuberculous mice. Body weight, survival, and numbers of viable tubercle bacilli, cultured at various intervals from lungs and spleens, were noted. In severe, acute, as well as in chronic, murine tuberculosis, the therapeutic results obtained with intermittent drug regimens compared favorably with the effects of continuous treatment. Since good results were observed with 1 single weekly dose of isoniazid, similar treatment schemes should be tried in ambulatory human patients. The possibility of being able to supervise the once-a-week drug intake might represent a considerable advantage over conventional regimens. Bacterial resistance to isoniazid develops at a slower rate in mice on intermittent treatment schemes than in animals that received isoniazid continuously. In order to be effective when given once a week, the single doses of isoniazid must be relatively large.

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