Redistribution of regional cerebral blood flow after glycerol infusion in acute cerebral infarction

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Abstract
Article abstract Regional cerebral blood flow and blood volume were measured before and after intravenous infusion of 10 percent glycerol in normal saline in a series of 24 patients with receni. ischemic or hemorrhagic cerebral infarction. Measurements were made by serial intracarotid injection of xenon 133 and technetium 99m and by the use of the gamma camera. Regional cerebral blood flow and blood volume, prior to glycerol infusion, were reduced more in patients with hemorrhagic infarction than in those with ischemic infarction. Border zones of relative hyperemia were present in both groups. After glycerol infusion (50 g), mean serum glycerol levels rose to 33.1 millimols, cerebrospinal fluid pressure was reduced, and regional cerebral blood flow and blood volume were increased in the ischemic zone of both groups, with a redistribution of blood from the hyperemic to the ischemic zones.

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