Acute and Delayed Emesis after Cisplatin-Based Regimen: Description and Prevention

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Abstract
Lorazepam, dexamethasone and high-dose metoclopramide were given to 54 patients to prevent emesis induced by cisplatin (50–120 mg/m2) on day 1, while prochlorperazine and dexamethasone were administered on days 2 and 3 for control of delayed emesis. Nausea and emesis were recorded from day 1 to day 8. This combination was well tolerated. Prevention on day 1 was complete for 72% of patients and satisfactory (≤2 emeses on day 1) in 85%. From days 2 to 8, no emesis, ≤ 2 and > 2 episodes occurred in 70, 11 and 19%, respectively. Overall control (days 1–8) was complete in 55.5% and satisfactory ≤2 emeses on day 1 and/or

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