Further Studies on the Relation Between Radiation Effects, Cell Viability, and Induced Resistance to Malignant Growth
- 1 December 1947
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 49 (6) , 724-732
- https://doi.org/10.1148/49.6.724
Abstract
Two mammary adenocarcinomata growing in the C3H and dba strain of mice, respectively, were irradiated in vitro with various doses of X-rays (Factors: 200 kV, 20 ma, 0.5 mm. Cu and 1.0 mm. Al filter, HVL 0.9 mm. Cu). The effect of irradiation was studied by implanting irradiated tumor fragments into mice and observing the latent period between implantation and growth and the percentage of takes in the new host. It was found, that for the adenocarcinoma grown in the dba mice a dose of 5,000 r/air was required to prevent the implant from producing a tumor, while for the adenocarcinoma grown in the C3H strain, a dose of 2,700 r/air was sufficient to produce the same result. In the light of these expts., it is suggested that certain intrinsic factors exist controlling the potentialities of tumor growth independent of his-tologic structure.Keywords
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