Antihyperglycemic Acetylenic Glucosides fromBidens pilosa
- 9 February 2000
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 66 (01) , 82-83
- https://doi.org/10.1055/s-0029-1243117
Abstract
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-β-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne (1) and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne (2). A 3 : 2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.Keywords
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