Comparative effects of chronic treatment with certain metals on cell division.

Publisher Website
Google Scholar
Abstract
A total of 17 metallic salts [sodium selenite, molybdate, arsenate, rubidium chloride, copper sulfate, magnesium sulfate, zinc chloride, strontium nitrate, cadmium chloride, mercuric chloride, ceric sulfate, cerium nitrate, lead acetate, vanadium pentoxide, cobalt chloride, cobalt sulfate, and nickel sulfate] belonging to 7 groups of the periodic table were applied in sublethal chronic doses on plant and animal cells in vivo for their comparative action on cell division. Usually within the members of a particular group inhibition of mitosis and induction of chromosomal abnormalities increased with increasing MW. There was a general direct proportionality with dosage applied and the cytotoxic action, though occasionally there was an increase in very low doses. These effects were more general in nature and could not be specifically attributed to any particular cell component. The amounts of total DNA and RNA showed a general decrease with increased dosage and period of treatment.

This publication has 0 references indexed in Scilit: